Publication

Intractable Vascular Disease and iPS Cell Research

2025

• RNF213 acts as a molecular switch for Cav-1 ubiquitination and phosphorylation in human cells.
  Choi J, Inoue R, Masuo Y, Shimizu Y, Sonomura K, Kim M, Kobayashi H, Harada KH, Mineharu Y, Koizumi A, Tezuka T, Youssefian S.
  Cells, 14:775, 2025
• RNF213-dependent EGFR and HER2 activation regulates specific downstream signaling pathways in human cancer cells.
  Fouad IM, Choi J, Huang Q, Kim M, Masuda S, Hejna JA, Mineharu Y, Koizumi A, Tezuka T, Youssefian S.
  Genes Cells, 30:e70033, 2025
• Bolus arrival time on dynamic contrast-enhanced magnetic resonance imaging using the GRASP technique: Characteristics and clinical utility in moyamoya disease.
  Ito S, Okuchi S, Fushimi Y, Fujimoto K, Yamamoto T, Nakajima S, Hidaka Y, Ibi Y, Sakata A, Otani S, Chihara H, Mineharu Y, Funaki T, Arakawa Y, Nakamoto Y.
  J Magn Reson Imaging, 62:1321-1333, 2025
• Deep learning reconstruction for improved image quality of ultra-high-resolution brain CT angiography: application in moyamoya disease.
  Ma Y, Nakajima S, Fushimi Y, Funaki T, Otani S, Takiya M, Matsuda A, Kozawa S, Fukushima Y, Okuchi S, Sakata A, Yamamoto T, Sakamoto R, Chihara H, Mineharu Y, Arakawa Y, Nakamoto Y.
  Jpn J Radiol, 43:1634-1642, 2025
• Peripheral blood GATA2 expression impacts RNF213 mutation penetrance and clinical severity in moyamoya disease.
  Mineharu Y, Kamata T, Tomoto M, Sato N, Tamada Y, Funaki T, Oichi Y, Harada KH, Koizumi A, Kimura T, Inoue I, Okuno Y, Miyamoto S, Arakawa Y.
  Stroke Vasc Neurol, 10:752-763, 2025
• RNF213 mutation associated with the progression from middle cerebral artery steno-occlusive disease to moyamoya disease.
  Sasagasako T, Mineharu Y, Funaki T, Fushimi Y, Chihara H, Park S, Nakajima K, Matsui Y, Okawa M, Kikuchi T, Arakawa Y.
  Transl Stroke Res, 16:1146-1155, 2025

2024

• Posterior cerebral artery involvement in unilateral moyamoya disease is exclusively ipsilateral and influenced by RNF213 mutation gene dose: The SUPRA Japan study.
  Mineharu Y, Takagi Y, Koizumi A, Morimoto T, Funaki T, Hishikawa T, Araki Y, Hasegawa H, Takahashi JC, Kuroda S, Houkin K, Miyamoto S, SUPRA Japan Study Group.
  J Stroke Cerebrovasc Dis, 33:107513, 2024
• Early radiological reduction of periventricular anastomosis after direct bypass surgery for adult moyamoya disease.
  Yamada H, Funaki T, Fushimi Y, Yamao Y, Hidaka Y, Kikuchi T, Mineharu Y, Okawa M, Yoshida K, Chihara H, Miyamoto S, Arakawa Y.
  J Neurosurg, 142:1428-1436, 2024

2023

• Transcallosal periventricular anastomosis in moyamoya disease: the fourth periventricular anastomosis and a potential predictor of hemorrhage.
  Yamao Y, Funaki T, Yamada H, Okawa M, Mineharu Y, Kikuchi T, Fushimi Y, Kataoka H, Yoshida K, Takahashi JC, Miyamoto S, Arakawa Y.
  J Stroke Cerebrovasc Dis, 32:107428, 2023

2022

• Increased abundance of Ruminococcus gnavus in gut microbiota is associated with moyamoya disease and non-moyamoya intracranial large artery disease.
  Mineharu Y, Nakamura Y, Sato N, Kamata T, Oichi Y, Fujitani T, Funaki T, Okuno Y, Miyamoto S, Koizumi A et al.
  Sci Rep, 12:20244, 2022
• Larger posterior revascularization associated with reduction of choroidal anastomosis in moyamoya disease: A quantitative angiographic analysis.
  Funaki T, Miyakoshi A, Kataoka H, Takahashi JC, Takagi Y, Yoshida K, Kikuchi T, Mineharu Y, Okawa M, Yamao Y, Fushimi Y, Miyamoto S.
  AJNR Am J Neuroradiol, 43:1279-1285, 2022
• Lack of association between seropositivity of vasculopathy-related viruses and moyamoya disease.
  Nakamura Y, Mineharu Y, Kamata T, Funaki T, Miyamoto S, Koizumi A, Harada KH.
  J Stroke Cerebrovasc Dis, 31:106509, 2022
• Characterization of moyamoya and middle cerebral artery diseases by carotid canal diameter and RNF213 pR4810K genotype.
  Oichi Y, Mineharu Y, Agawa Y, Morimoto T, Funaki T, Hitomi T, Kobayashi H, Todo K, Tani S, Imamura H, Yoshida K, Kataoka H, Koizumi A, Sakai N, Miyamoto S.
  J Stroke Cerebrovasc Dis, 31:106481, 2022

2021

• Genetic and nongenetic factors for contralateral progression of unilateral moyamoya disease: the first report from the SUPRA Japan Study Group.
  Mineharu Y, Takagi Y, Koizumi A, Morimoto T, Funaki T, Hishikawa T, Araki Y, Hasegawa H, Takahashi JC, Kuroda S, Houkin K, Miyamoto S.
  J Neurosurg, 136:1005-1014, 2021
• Plasticity of the bony carotid canal and its clinical use for assessing negative remodeling of the internal carotid artery.
  Oichi Y, Mineharu Y, Agawa Y, Morimoto T, Funaki T, Fushimi Y, Yoshida K, Kataoka H, Miyamoto S.
  PLoS One, 16:e0261235, 2021
• RNF213 and GUCY1A3 in Moyamoya Disease: Key Regulators of Metabolism, Inflammation, and Vascular Stability.
  Mineharu Y, Miyamoto S.
  Front Neurol, 12:687088, 2021

2020

• Cortical distribution of fragile periventricular anastomotic collateral vessels in moyamoya disease: An exploratory cross-sectional study of Japanese patients with moyamoya disease.
  Miyakoshi A, Funaki T, Fushimi Y, Nakae T, Okawa M, Kikuchi T, Kataoka H, Yoshida K, Mineharu Y, Matsuhashi M, Nakatani E, Miyamoto S.
  AJNR Am J Neuroradiol, 41:2243-2249, 2020
• Revascularization surgery in childhood associated with a low incidence of microbleeds in adult patients with moyamoya.
  Yamao Y, Takahashi JC, Funaki T, Mineharu Y, Kikuchi T, Okada T, Togashi K, Miyamoto S.
  World Neurosurg, 133:e716-e721, 2020
• Unilateral Moyamoya Disease: A Distinct Entity?
  Yohei Mineharu and Susumu Miyamoto.
  Moyamoya Disease: Current Knowledge and Future Perspectives, Springer, P33-34, 2020

2019

• The targeted bypass strategy for preventing hemorrhage in moyamoya disease: Technical note.
  Funaki T, Kataoka H, Yoshida K, Kikuchi T, Mineharu Y, Okawa M, Yamao Y, Miyamoto S.
  Neurol Med Chir (Tokyo), 59:517-522, 2019
• Identification of the bleeding point in hemorrhagic moyamoya disease using fusion images of susceptibility-weighted imaging and time-of-flight MRA.
  Miyakoshi A, Funaki T, Fushimi Y, Kikuchi T, Kataoka H, Yoshida K, Mineharu Y, Takahashi JC, Miyamoto S.
  AJNR Am J Neuroradiol, 40:1674-1680, 2019
• Restoration of periventricular vasculature after direct bypass for moyamoya disease: intra-individual comparison.
  Miyakoshi A, Funaki T, Takahashi JC, Takagi Y, Kikuchi T, Yoshida K, Kataoka H, Mineharu Y, Okawa M, Yamao Y et al.
  Acta Neurochir, 161:947-954, 2019

2018

• Initially missed or delayed diagnosis of subarachnoid hemorrhage: A nationwide survey of contributing factors and outcomes in Japan.
  Takagi Y, Hadeishi H, Mineharu Y, Yoshida K, Ogasawara K, Ogawa A, Miyamoto S.
  J Stroke Cerebrovasc Dis, 27:871-877, 2018
• Dysregulation of RNF213 promotes cerebral hypoperfusion.
  Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada KH, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A.
  Sci Rep, 8:3607, 2018

2017

• RNF213 pR4810K variant and intracranial arterial stenosis or occlusion in relatives of patients with moyamoya disease.
  Matsuda Y, Mineharu Y, Kimura M, Takagi Y, Kobayashi H, Hitomi T, Harada KH, Uchihashi Y, Funaki T, Miyamoto S, Koizumi A.
  J Stroke Cerebrovasc Dis, 26:1841-1847, 2017
• Rapid contralateral progression of focal cerebral arteriopathy distinguished from RNF213-related moyamoya disease and fibromuscular dysplasia.
  Araki Y, Takagi Y, Mineharu Y, Kobayashi H, Miyamoto S, Wakabayashi T.
  Childs Nerv Syst, 33:1405-1409, 2017
• Significant association of RNF213 pR4810K, a moyamoya susceptibility variant, with coronary artery disease.
  Morimoto T, Mineharu Y, Kobayashi H, Harada KH, Funaki T, Takagi Y, Sakai N, Miyamoto S, Koizumi A.
  PLoS One, 12:e0175649, 2017
• Endovascular parent-artery occlusion of large or giant unruptured internal carotid artery aneurysms: A long-term single-center experience.
  Shimizu K, Imamura H, Mineharu Y, Adachi H, Sakai C, Sakai N.
  J Clin Neurosci, 37:73-78, 2017
• Significance of RNF213 in Clinical Management in Japan.
  Mineharu Y, Takagi Y and Miyamoto S.
  Moyamoya Disease Explored Through RNF213: Genetics, Molecular Pathology, and Clinical Sciences. Springer, Chapter 11, p137-150, 2017

2016

• Significant association of the RNF213 pR4810K polymorphism with quasi-moyamoya disease.
  Morimoto T, Mineharu Y, Kobayashi H, Harada KH, Funaki T, Takagi Y, Sakai N, Miyamoto S, Koizumi A.
  J Stroke Cerebrovasc Dis, 25:2632-2636, 2016
• Periventricular anastomosis in moyamoya disease: detecting fragile collateral vessels with MR angiography.
  Funaki T, Takahashi JC, Yoshida K, Takagi Y, Fushimi Y, Kikuchi T, Mineharu Y, Okada T, Morimoto T, Miyamoto S.
  J Neurosurg, 124:1766-1772, 2016
• Histopathological characteristics of distal middle cerebral artery in adult and pediatric patients with moyamoya disease.
  Takagi Y, Hermanto Y, Takahashi JC, Funaki T, Kikuchi T, Mineharu Y, Yoshida K, Miyamoto S.
  Neurol Med Chir (Tokyo), 56:345-349, 2016

2015

• Endovascular treatment of unruptured paraclinoid aneurysms: Single-center experience with 400 cases and literature review.
  Shimizu K, Imamura H, Mineharu Y, Adachi H, Sakai C, Sakai N.
  AJNR Am J Neuroradiol, 37:679-685, 2015

2013

• Rapid progression of unilateral moyamoya disease in a patient with a family history and an RNF213 risk variant.
  Mineharu Y, Takagi Y, Takahashi JC, Hashikata H, Liu W, Hitomi T, Kobayashi H, Koizumi A, Miyamoto S.
  Cerebrovasc Dis, 36:155-157, 2013

2011

• Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development.
  Liu W#, Morito D#, Takashima S#, Mineharu Y# (equal contribution, first author), Kobayashi H#, Hitomi T#, Hashikata H#, Matsuura N, Yamazaki S, Toyoda A, Kikuta K, Takagi Y, Harada KH, Fujiyama A, Herzig R, Krischek B, Zou L, Kim JE, Kitakaze M, Miyamoto S, Nagata K, Hashimoto N, Koizumi A.
  PLoS One, 6:e22542, 2011

2010

• Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients.
  Hashikata H, Liu W, Inoue K, Mineharu Y, Yamada S, Nanayakkara S, Matsuura N, Hitomi T, Takagi Y, Hashimoto N, Miyamoto S, Koizumi A.
  Stroke, 41:1138-1144, 2010
• A rare Asian founder polymorphism of Raptor may explain the high prevalence of moyamoya disease among East Asians and its low prevalence among Caucasians.
  Liu W, Hashikata H, Inoue K, Matsuura N, Mineharu Y, Kobayashi H, Kikuta K, Takagi Y, Hitomi T, Krischek B, Zou LP, Fang F, Herzig R, Kim JE, Kang HS, Oh CW, Tregouet DA, Hashimoto N, Koizumi A.
  Environ Health Prev Med, 15:94-104, 2010

2009

• Autosomal dominant moyamoya disease maps to chromosome 17q25.3.
  Mineharu Y, Liu W, Inoue K, Matsuura N, Inoue S, Takenaka K, Ikeda H, Houkin K, Takagi Y, Kikuta K, Nozaki K, Hashimoto N, Koizumi A.
  Neurology, 70:2357-2363, 2009

2008

• Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23.
  Mineharu Y, Inoue K, Inoue S, Yamada S, Nozaki K, Hashimoto N, Koizumi A.
  J Hum Genet, 53:325-332, 2008

2007

• Model-based linkage analyses confirm chromosome 19q13.3 as a susceptibility locus for intracranial aneurysm.
  Mineharu Y, Inoue K, Inoue S, Yamada S, Nozaki K, Hashimoto N, Koizumi A.
  Stroke, 38:1174-1178, 2007

2006

• Inheritance pattern of familial moyamoya disease: autosomal dominant mode and genomic imprinting.
  Mineharu Y, Takenaka K, Yamakawa H, Inoue K, Ikeda H, Kikuta KI, Takagi Y, Nozaki K, Hashimoto N, Koizumi A.
  J Neurol Neurosurg Psychiatry, 77:1025-1029, 2006
• Association analysis of common variants of ELN, NOS2A, APOE and ACE2 to intracranial aneurysm.
  Mineharu Y, Inoue K, Inoue S, Yamada S, Nozaki K, Takenaka K, Hashimoto N, Koizumi A.
  Stroke, 37:1189-1194, 2006
• Search on chromosome 17 centromere reveals TNFRSF13B as a susceptibility gene for intracranial aneurysm: a preliminary study.
  Inoue K, Mineharu Y, Inoue S, Yamada S, Matsuda F, Nozaki K, Takenaka K, Hashimoto N, Koizumi A.
  Circulation, 113:2002-2010, 2006

Medical AI and Digital Health Research

2026

• Real-time imaging of platelet dynamics in engineered arterial, venous, and cancer-associated thrombotic microenvironments.
  Deng Y, Zhou Y, Tay HM, Wang H, Chen J, Luo Y, Zhang H, Zhang C, Ibayashi Y, Paiè P, Nishikawa M, Mineharu Y, Morishita E, Yatomi Y, Hou HW, Goda K.
  Biofabrication, 18:015022, 2026

2025

• Association between ischemic stroke and hyperintense plaques detected by high-resolution vessel wall MRI in Japanese patients with intracranial atherosclerotic disease.
  Takayama N, Maki T, Fushimi Y, Okawa M, Mineharu Y, Yamada K, Yang T, Yamamoto Y, Suzuki K, Yasuda K, Grinstead J, Ahn S, Matsumoto R, Arakawa Y, Yoshida K.
  Front Stroke, 4:1610666, 2025
• Usefulness of the Scalp Electroencephalography over Bone Defect for the Decoding of Muscle Activity.
  Yamashita T, Sawada M, Demura A, Aoyama S, Yao Y, Chihara H, Ikedo T, Hattori EY, Sano N, Takada S, Tanji M, Mineharu Y, Kikuchi T, Arakawa Y.
  World Neurosurg, 205:124670, 2025
• Predicting measurement continuity in home blood pressure monitoring using machine learning.
  Matsumoto A, Mineharu Y, Kohjitani H, Koshimizu H, Okuno Y.
  Hypertens Res, epub, 2025
• Out-of-distribution reject option method for dataset shift problem in early disease onset prediction.
  Tosaki T, Uchino E, Kojima R, Mineharu Y, Okamoto Y, Arita M, Miyai N, Tamada Y, Mikami T, Murashita K, Nakaji S, Okuno Y.
  Sci Rep, 15:19240, 2025

2024

• Idiopathic pulmonary fibrosis-specific Bayesian network integrating extracellular vesicle proteome and clinical information.
  Tomoto M, Mineharu Y, Sato N, Tamada Y, Nogami-Itoh M, Kuroda M, Adachi J, Takeda Y, Mizuguchi K, Kumanogoh A, Natsume-Kitatani Y, Okuno Y.
  Sci Rep, 14:1315, 2024
• Development of extended pharmacokinetic models for propofol based on measured blood and brain concentrations.
  Kawata M, Yonezawa A, Mineharu Y, Itohara K, Mizota T, Matsui Y, Kikuchi T, Yamao Y, Hattori EY, Hamada M, Hira D, Furukawa K, Miyamoto S, Terada T, Matsubara K, Arakawa Y.
  Sci Rep, 14:6326, 2024
• Interpretable machine learning-based individual analysis of acute kidney injury in immune checkpoint inhibitor therapy.
  Sakuragi M, Uchino E, Sato N, Matsubara T, Ueda A, Mineharu Y, Kojima R, Yanagita M, Okuno Y.
  PLoS One, 19:e0298673, 2024
• Postoperative Karnofsky performance status prediction in patients with IDH wild-type glioblastoma: A multimodal approach integrating clinical and deep imaging features.
  Sasagasako T, Ueda A, Mineharu Y, Mochizuki Y, Doi S, Park S, Terada Y, Sano N, Tanji M, Arakawa Y, Okuno Y.
  PLoS One, 19:e0303002, 2024
• Common and distinct risk profiles of asymptomatic extra- and intracranial atherosclerosis in the Nagahama cohort.
  Suzuki M, Mineharu Y, Okawa M, Yoshida K, Nagata M, Yang T, Suzuki K, Takayama N, Yamamoto Y, Tabara Y, Miyamoto S, Arakawa Y, Matsuda F.
  J Stroke Cerebrovasc Dis, 33:107782, 2024

2022

• Deep imaging flow cytometry.
  Huang K, Matsumura H, Zhao Y, Herbig M, Yuan D, Mineharu Y, Harmon J, Findinier J, Yamagishi M, Ohnuki S, Nitta N, Grossman AR, Ohya Y, Mikami H, Isozaki A, Goda K.
  Lab Chip, 22:876-889, 2022

2010

• Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women.
  Mineharu Y, Koizumi A, Wada Y, Iso H, Watanabe Y, Date C, Yamamoto A, Kikuchi S, Inaba Y, Toyoshima H, Kondo T, Tamakoshi A, JACC study Group.
  J Epidemiol Community Health, 65:230-240, 2010

Basic Research on Brain Tumors

2022

• A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice.
  Hattori EY, Masuda T, Mineharu Y, Mikami M, Terada Y, Matsui Y, Kubota H, Hirata M, Kataoka TR, Nakahata T, Ikeda S, Miyamoto S, Sugiyama H, Arakawa Y, Kamikubo Y.
  Commun Biol, 5:939, 2022
• Chlorambucil-conjugated PI-polyamides (Chb-M’), a transcription inhibitor of RUNX family, has an anti-tumor activity against SHH-type medulloblastoma with p53 mutation.
  Matsui Y, Mineharu Y, Noguchi Y, Hattori EY, Kubota H, Hirata M, Miyamoto S, Sugiyama H, Arakawa Y, Kamikubo Y.
  Biochem Biophys Res Commun, 620:150-157, 2022

2019

• Human pluripotent stem cell-derived tumor model uncovers the embryonic stem cell signature as a key driver in atypical teratoid/rhabdoid tumor.
  Terada Y, Jo N, Arakawa Y, Sakakura M, Yamada Y, Ukai T, Kabata M, Mitsunaga K, Mineharu Y, Ohta S, Nakagawa M, Miyamoto S, Yamamoto T, Yamada Y.
  Cell Rep, 26:2608-2621.e6, 2019

2018

• PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes.
  Liu B, Arakawa Y, Yokogawa R, Tokunaga S, Terada Y, Murata D, Matsui Y, Fujimoto KI, Fukui N, Tanji M, Mineharu Y, Minamiguchi S, Miyamoto S.
  PLoS One, 13:e0194594, 2018
• High programmed cell death 1 ligand-1 expression: association with CD8+ T-cell infiltration and poor prognosis in human medulloblastoma.
  Murata D, Mineharu Y, Arakawa Y, Liu B, Tanji M, Yamaguchi M, Fujimoto KI, Fukui N, Terada Y, Yokogawa R, Yamaguchi M, Minamiguchi S, Miyamoto S.
  J Neurosurg, 128:710-716, 2018

2017

• Single vs. combination immunotherapeutic strategies for glioma.
  Chandran M, Candolfi M, Shah D, Mineharu Y, Yadav V, Koschmann C, Asad AS, Lowenstein PR, Castro MG.
  Expert Opin Biol Ther, 00:14712598.2017.1305353, 2017

2016

• Recent advances and future of immunotherapy for glioblastoma.
  Kamran N, Calinescu A, Candolfi M, Chandran M, Mineharu Y, Asad AS, Koschmann C, Nunez FJ, Lowenstein PR, Castro MG.
  Expert Opin Biol Ther, 16:1245-1264, 2016

2015

• Overview of current immunotherapeutic strategies for glioma.
  Calinescu A-A, Mineharu Y, Castro MG.
  Immunotherapy, 7:1073-1104, 2015

2014

• Blockade of mTOR signaling via rapamycin combined with immunotherapy augments antiglioma cytotoxic and memory T-cell functions.
  Mineharu Y, Kamran N, Lowenstein PR, Castro MG.
  Mol Cancer Ther, 13:3024-3036, 2014
• Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy.
  Baker GJ, Yadav VN, Motsch S, Koschmann C, Calinescu AA, Mineharu Y, Camelo-Piragua SI, Orringer D, Bannykh S, Nichols WS, deCarvalho AC, Mikkelsen T, Castro MG.
  Neoplasia, 16:543-561, 2014
• Immunotherapies for brain cancer: from preclinical models to human trials.
  Wilson TJ, Candolfi M, Assi H, Ayala MM, Mineharu Y, Hervey-Jumper SL, Lowenstein PR and Castro MG.
  TUMORS OF THE CENTRAL NERVOUS SYSTEM, Volume 13, Chapter 25, p239-251, 2014

2013

• Dendritic cell-based immunotherapy for glioma: multiple regimens and implications in clinical trials.
  Mineharu Y, Castro MG, Lowenstein PR, Sakai N, Miyamoto S.
  Neurol Med Chir, 53:741-754, 2013

2012

• Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.
  Mineharu Y, Muhammad AK, Yagiz K, Candolfi M, Kroeger KM, Xiong W, Puntel M, Liu C, Levy E, Lugo C, Kocharian A, Allison JP, Curran MA, Lowenstein PR, Castro MG.
  Neurotherapeutics, 9:827-843, 2012
• Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics.
  Candolfi M, King GD, Yagiz K, Curtin JF, Mineharu Y, Muhammad AK, Puntel M, Kroeger KM, Liu C, Lee S, Curtin JF, King GD, Lerner J, Sato K, Mineharu Y, Xiong W, Lowenstein PR, Castro MG.
  Neoplasia, 14:757-770, 2012

2011

• Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design.
  Mineharu Y, King GD, Muhammad AK, Bannykh S, Kroeger KM, Liu C, Lowenstein PR, Castro MG.
  Clin Cancer Res, 17:4705-4718, 2011
• Gene therapy and targeted toxins for glioma.
  Castro MG, Candolfi M, Kroeger K, King GD, Curtin JF, Yagiz K, Mineharu Y, Assi H, Wibowo M, Ghulam Muhammad AK, Foulad D, Puntel M, Lowenstein PR.
  Curr Gene Ther, 11:155-180, 2011

2009

• Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression.
  Ghulam Muhammad AK, Candolfi M, King GD, Yagiz K, Foulad D, Mineharu Y, Kroeger KM, Treuer KA, Nichols WS, Sanderson NS, Yang J, Khayznikov M, Van Rooijen N, Lowenstein PR, Castro MG.
  Clin Cancer Res, 15:6113-6127, 2009
• Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity.
  Candolfi M, Yagiz K, Foulad D, Alzadeh GE, Tesarfreund M, Muhammad AK, Puntel M, Kroeger KM, Liu C, Lee S, Curtin JF, King GD, Lerner J, Sato K, Mineharu Y, Xiong W, Lowenstein PR, Castro MG.
  Clin Cancer Res, 15:4401-4414, 2009

Clinical Research on Brain Tumors

2025

• High-grade gliomas derived from an ovarian mature teratoma: clonal dynamics and genetic insights.
  Yamauchi K, Hamanishi J, Watanabe K, Kakiuchi N, Takeuchi Y, Katsuragawa H, Yamanoi K, Motohashi T, Hosoe Y, Yamaguchi K, Yamaguchi K, Imoto S, Tabata T, Furukawa Y, Mineharu Y, Arakawa Y, Ogawa S, Minamiguchi S, Mandai M.
  Int Cancer Conf J, 14:421-427, 2025
• Successful management of recurrent multiple intracerebral TFE3-rearranged epithelioid hemangioendothelioma with repeated intervention and active surveillance: illustrative case.
  Matsui Y, Takada S, Takeuchi Y, Tokunaga S, Hattori EY, Ikeda H, Sano N, Tanji M, Mineharu Y, Arakawa Y.
  J Neurosurg Case Lessons, 10:CASE25416, 2025
• Chronic expanding hematoma following Gamma Knife irradiation for primary central nervous system lymphoma: illustrative case.
  Hattori EY, Terada Y, Takeuchi Y, Makino Y, Takada S, Sano N, Tanji M, Mineharu Y, Arakawa Y.
  J Neurosurg Case Lessons, 9:CASE258, 2025
• Efficacy and safety of carmustine wafers, followed by radiation, temozolomide, and bevacizumab therapy, for newly diagnosed glioblastoma with maximal resection.
  Kanamori M, Shibahara I, Shimoda Y, Akiyama Y, Beppu T, Ohba S, Enomoto T, Ono T, Mitobe Y, Hanihara M, Mineharu Y, Ishida J, Asano K, Yoshida Y, Natsumeda M, Nomura S, Abe T, Yonezawa H, Katakura R, Shibui S, Kuroiwa T, Suzuki H, Takei H, Matsushita H, Saito R, Arakawa Y, Sonoda Y, Hirose Y, Kumabe T, Yamaguchi T, Endo H, Tominaga T.
  Int J Clin Oncol, 30:51-61, 2025
• Dummy run study for outlining and plan quality of intensity-modulated radiotherapy in elderly patients with newly diagnosed glioblastoma: The Japan Clinical Oncology Group study JCOG1910 (AgedGlio-PIII).
  Ono T, Uto M, Mineharu Y, Arakawa Y, Nakamoto Y, Nakamura M, Nishio T, Igaki H, Nihei K, Ishikura S, Narita Y, Mizowaki T, Brain Tumor Study Group and Radiation Therapy Study Group of the Japan Clinical Oncology Group.
  Radiat Oncol, 20:32, 2025
• A multicenter phase II trial of nimustine hydrochloride administered via convection-enhanced delivery in children with DIPG.
  Saito R, Kanamori M, Arakawa Y, Mineharu Y, Aihara Y, Chiba K, Kumabe T, Shibahara I, Sonoda Y, Matsuda K, Kinoshita M, Sato A, Takahashi F, Tominaga T.
  Cancer Sci, 116:1679-1690, 2025
• RANO 2.0: critical updates and practical considerations for radiological assessment in neuro-oncology.
  Sakata A, Fushimi Y, Oshima S, Uto M, Mineharu Y, Nakajima S, Okuchi S, Yamamoto T, Otani S, Ikeda S, Takada S, Mizowaki T, Arakawa Y, Nakamoto Y.
  Jpn J Radiol, 43:1557-1574, 2025
• Diffuse midline glioma H3K27-altered with thoracic epidural metastasis: illustrative case.
  Sumita K, Sawada M, Hattori EY, Sano N, Takada S, Tanji M, Mineharu Y, Kikuchi T, Arakawa Y.
  J Neurosurg Case Lessons, 10:CASE25249, 2025
• Cognitive and social functions of craniopharyngioma and germ cell tumor differ in patients with and without apathy.
  Tabata A, Ueda K, Umeda K, Funaki T, Ueno T, Mineharu Y, Tanji M, Kikuchi T, Komaki M, Miyamoto S, Murai T, Arakawa Y.
  PCN Rep, 4:e70068, 2025
• Potential predictors of awake surgery failure for insular glioma.
  Takada S, Hattori EY, Sano N, Sawada M, Tanji M, Mineharu Y, Kikuchi T, Arakawa Y.
  Sci Rep, 15:17953, 2025
• Phase II trial of pathology-based tripartite treatment stratification for patients with CNS germ cell tumors: A long-term follow-up study.
  Takami H, Matsutani M, Suzuki T, Takabatake K, Fujimaki T, Okamoto M, Yamaguchi S, Kanamori M, Matsuda K, Sonoda Y, Natsumeda M, Ichinose T, Nakada M, Muroi A, Ishikawa E, Takahashi M, Narita Y, Tanaka S, Saito N, … Nishikawa R.
  Neuro Oncol, 27:828-840, 2025
• Multiport combined endoscopic endonasal and transorbital approach to orbital schwannoma.
  Tanji M, Sano N, Hashimoto J, Kikuchi M, Matsunaga M, Kitada Y, Yamamoba M, Takeuchi Y, Makino Y, Hattori EY, Terada Y, Mineharu Y, Arakawa Y.
  Surg Neurol Int, 16:98, 2025
• Glioblastoma with markedly reduced contrast enhancement after corticosteroid administration: Increased density and reduced diffusion capability are noteworthy.
  Toda D, Nakajima S, Fushimi Y, Kitano T, Tanji M, Mineharu Y, Takeuchi Y, Haga H, Arakawa Y, Nakamoto Y.
  Radiol Case Rep, 20:3186-3190, 2025
• Image-based re-evaluation of the JCOG0911 study focusing on tumor volume and survival, disease progression diagnosis, and radiomic prognostication for newly diagnosed glioblastoma.
  Kinoshita M, Fushimi Y, Masumoto T, Sasaki K, Sekita T, Natsume A, Wakabashi T, Komori T, Tsuzuki S, Muragaki Y, Motomura K, Saito R, Sato K, Beppu T, Takahashi M, Kuroda J, Sonoda Y, Kobayashi K, Mishima K, Mitsuya K, Yamasaki F, Inoue A, Matsutani T, Nakamura H, Yamaguchi S, Ishikawa E, Nakaya M, Tanaka S, Ujifuku K, Uchida H, Kanamori M, Otani R, Kijima N, Nishida N, Yoshino A, Mineharu Y, Arakawa Y, Fukuda H, Narita Y, Members of Japan Clinical Oncology Group Brain Tumor Study Group (JCOG-BTSG).
  Magn Reson Med Sci, 24:2024-0103, 2025

2024

• Intracranial pleomorphic liposarcoma misclassified as a pleomorphic xanthoastrocytoma by a DNA methylation classifier: illustrative case.
  Go K, Makino Y, Takeuchi Y, Minamiguchi S, Takada S, Sano N, Tanji M, Mineharu Y, Hojo M, Haga H, Arakawa Y.
  J Neurosurg Case Lessons, 8:CASE24465, 2024
• Performance status improvement and advances in systemic treatment after brain metastases resection: a retrospective single-center cohort study of non-small cell lung cancer patients.
  Hosoya K, Ozasa H, Tanji M, Yoshida H, Ajimizu H, Tsuji T, Yoshida H, Terada Y, Sano N, Mineharu Y, Miyamoto S, Hirai T, Arakawa Y.
  BMC Cancer, 24:1030, 2024
• Clinical and imaging characteristics of supratentorial glioma with IDH2 mutation.
  Ikeda S, Sakata A, Arakawa Y, Mineharu Y, Makino Y, Takeuchi Y, Fushimi Y, Okuchi S, Nakajima S, Otani S, Nakamoto Y.
  Neuroradiology, 66:973-981, 2024
• Impact of tumor-treating fields on the survival of Japanese patients with newly diagnosed glioblastoma: A multicenter, retrospective cohort study.
  Kanamori M, Tsuzuki S, Shibahara I, Saito K, Shimoda Y, Tanaka K, Yamaguchi S, Natsumeda M, Matsutani T, Hanihara M, Nakada M, Kuroda J, Matsuda K, Yoshimoto K, Yonezawa U, Sonoda Y, Takano K, Yonezawa H, Otani Y, Nakahara Y, Uchida M, Nonaka M, Mineharu Y, Kitamura Y, Yamashita S, Yamauchi T, Miyake Y, Deguchi S, Beppu T, Tamura K, Koizumi S, Hirose Y, Asano K, Hiruta R, Kinoshita M, Miyake K, Nakayama N, Inoue A, Ono T, Sasaki T, Akiyama Y, Fukami S, Yoshino A, Kawanishi Y, Asanome T, Yamaguchi T, Takahashi M, Yamasaki F, Arakawa Y, Narita Y.
  Neurooncol Adv, 6:vdae176, 2024
• Trochlear nerve schwannoma with concomitant osimertinib-responsive stage IV lung adenocarcinoma: illustrative case.
  Kashiwagi S, Tanji M, Matsuoka T, Sano N, Ozasa H, Natori D, Takeuchi Y, Makino Y, Yamamoto Hattori E, Terada Y, Mineharu Y, Arakawa Y.
  J Neurosurg Case Lessons, 8:CASE24144, 2024
• Cost of medical care for malignant brain tumors at hospitals in the Japan Clinical Oncology Group brain-tumor study group.
  Motomura K, Sasaki K, Sugii N, Yamaguchi S, Inoue H, Oshima A, Tanaka K, Otani Y, Shirahata M, Shibahara I, Nagane M, Tsuzuki S, Matsutani T, Tsukamoto Y, Kijima N, Asano K, Ohno M, Inoue A, Mineharu Y, Miyake K, Mitobe Y, Hanihara M, Kawanishi Y, Deguchi S, Saito M, Matsuda R, Ujifuku K, Arita H, Sato Y, Yamashita S, Yonezawa U, Yamaguchi J, Momii Y, Ogawa T, Kambe A, Ohba S, Fukai J, Saito N, Kinoshita M, Sumi K, Otani R, Uzuka T, Takebe N, Koizumi S, Saito R, Arakawa Y, Narita Y, Members of Japan Clinical Oncology Group Brain Tumor Study Group (JCOG-BTSG).
  Jpn J Clin Oncol, 54:1123-1131, 2024
• Hypofractionated radiotherapy combined with bevacizumab plus low-dose ifosfamide, carboplatin, and etoposide as second-line chemoradiotherapy for progressing spinal diffuse midline glioma, H3K27-altered: illustrative case.
  Nakayasu S, Tanji M, Uto M, Takeuchi Y, Makino Y, Yamamoto Hattori E, Terada Y, Sano N, Mineharu Y, Mizowaki T, Arakawa Y.
  J Neurosurg Case Lessons, 8:CASE2464, 2024
• Impact of collagen matrix on reconstructive material selection and postoperative complications in endoscopic endonasal skull base surgery.
  Tanji M, Oishi M, Sano N, Terada Y, Kikuchi M, Nakagawa T, Sakamoto T, Matsunaga M, Kuwata F, Kitada Y, Yamashita M, Mineharu Y, Miyamoto S, Arakawa Y.
  J Neurosurg, 141:204-211, 2024

2023

• The first-in-human phase I study of a brain-penetrant mutant IDH1 inhibitor DS-1001 in patients with recurrent or progressive IDH1-mutant gliomas.
  Natsume A, Arakawa Y, Narita Y, Sugiyama K, Hata N, Muragaki Y, Shinojima N, Kumabe T, Saito R, Motomura K, Mineharu Y, Miyakita Y, Yamasaki F, Matsushita Y, Ichimura K, Ito K, Tachibana M, Kakurai Y, Okamoto N, Asahi T, Nishijima S, Yamaguchi T, Tsubouchi H, Nakamura H, Nishikawa R.
  Neuro Oncol, 25:326-336, 2023
• A scalp dose threshold for preventing permanent alopecia in scalp-avoidance whole-brain irradiation with volumetric modulated arc radiation therapy for pediatric patients with medulloblastomas.
  Torizuka D, Uto M, Umeda K, Kamitori T, Iwai A, Saida S, Kato I, Mineharu Y, Arakawa Y, Takita J, Mizowaki T.
  Int J Radiat Oncol Biol Phys, 116:889-893, 2023
• Seizure control by adding on other anti-seizure medication on seizure during levetiracetam administration in patients with glioma-related epilepsy.
  Hattori EY, Arakawa Y, Mineharu Y, Furukawa K, Terada Y, Yamao Y, Tanji M, Kikuchi T, Miyamoto S.
  BMC Cancer, 23:849, 2023
• Evaluation of isocitrate dehydrogenase mutation in 2021 world health organization classification grade 3 and 4 glioma adult-type diffuse gliomas with 18F-fluoromisonidazole PET.
  Wang Y, Fushimi Y, Arakawa Y, Shimizu Y, Sano K, Sakata A, Nakajima S, Okuchi S, Hinoda T, Oshima S, Otani S, Ishimori T, Tanji M, Mineharu Y, Yoshida K, Nakamoto Y.
  Jpn J Radiol, 41:1255-1264, 2023
• High intratumoral susceptibility signal grade on susceptibility-weighted imaging: a risk factor for hemorrhage after stereotactic biopsy.
  Tanji M, Mineharu Y, Sakata A, Okuchi S, Fushimi Y, Oishi M, Terada Y, Sano N, Yamao Y, Arakawa Y, Yoshida K, Miyamoto S.
  J Neurosurg, 138:120-127, 2023
• Telomerase reverse transcriptase promoter mutation and histologic grade in IDH wild-type histological lower-grade gliomas: The value of perfusion-weighted image, diffusion-weighted image, and 18F-FDG-PET.
  Ikeda S, Sakata A, Fushimi Y, Okuchi S, Arakawa Y, Makino Y, Mineharu Y, Nakajima S, Hinoda T, Yoshida K, Miyamoto S, Nakamoto Y.
  Eur J Radiol, 159:110658, 2023

2022

• Correlation between brain functional connectivity and neurocognitive function in patients with left frontal glioma.
  Ueda M, Usami K, Yamao Y, Yamawaki R, Umaba C, Liang N, Nankaku M, Mineharu Y, Honda M, Hitomi T, Ikeguchi R, Ikeda A, Miyamoto S, Matsuda S, Arakawa Y.
  Sci Rep, 12:18302, 2022
• A novel SREBF1::NACC1 gene fusion in an unclassifiable intracranial tumour.
  Takeuchi Y, Mineharu Y, Arakawa Y, Hara M, Oichi Y, Kamata T, Fukuyama K, Yamamoto Y, Yamanaka T, Kakiuchi N, Hiratomo E, Hirata M, Yokoo H, Hirose T, Minamiguchi S, Ogawa S, Muto M, Miyamoto S, Haga H.
  Neuropathol Appl Neurobiol, 48:e12843, 2022
• Whole-genome sequencing analysis of an atypical teratoid/rhabdoid tumor in a patient with Phelan-McDermid syndrome: a case report and systematic review.
  Yamashita H, Arakawa Y, Terada Y, Takeuchi Y, Mineharu Y, Sumiyoshi S, Tokunaga S, Nakajima K, Kawabata N, Tanaka K, Tanji M, Umeda K, Minamiguchi S, Ogawa S, Haga H, Takita J, Miyamoto S.
  Brain Tumor Pathol, 39:232-239, 2022
• Optimal managements of elderly patients with glioblastoma.
  Arakawa Y, Mineharu Y, Uto M, Mizowaki T.
  Jpn J Clin Oncol, 52:833-842, 2022
• The association of ectopic craniopharyngioma in the fourth ventricle with familial adenomatous polyposis: illustrative case.
  Uemura H, Tanji M, Natsuhara H, Takeuchi Y, Hoki M, Sugimoto A, Minamiguchi S, Kawasaki H, Torishima M, Kosugi S et al.
  J Neurosurg Case Lessons, 3:CASE21572, 2022
• Malignant transformation of central neurocytoma with dissemination 17 years after initial treatment: illustrative case.
  Kojima K, Arakawa Y, Takeuchi Y, Terada Y, Tanji M, Mineharu Y, Haga H, Miyamoto S.
  J Neurosurg Case Lessons, 3:CASE21610, 2022
• Central nervous system mature teratoma producing carbohydrate antigen 19-9: illustrative case.
  Takeuchi S, Arakawa Y, Takeuchi Y, Minamiguchi S, Tanji M, Mineharu Y, Haga H, Miyamoto S.
  J Neurosurg Case Lessons, 4:CASE22230, 2022
• A nationwide questionnaire survey on awake craniotomy in Japan.
  Kawata M, Fukui A, Mineharu Y, Kikuchi T, Yamao Y, Yamamoto Hattori E, Shiraki A, Mizota T, Furukawa K, Miyamoto S, Yonezawa A, Arakawa Y.
  Neurol Med Chir (Tokyo), 62:278-285, 2022
• Intraoperative cerebrospinal fluid leak graded by Esposito grade is a predictor for diabetes insipidus after endoscopic endonasal pituitary adenoma resection.
  Tanji M, Mineharu Y, Kikuchi M, Nakagawa T, Sakamoto T, Yamashita M, Matsunaga M, Kuwata F, Kitada Y, Terada Y, Arakawa Y, Kataoka H, Yoshida K, Miyamoto S.
  World Neurosurg, 158:e896-e902, 2022
• Intraoperative hand strength as an indicator of consciousness during awake craniotomy: a prospective, observational study.
  Umaba C, Mineharu Y, Liang N, Mizota T, Yamawaki R, Ueda M, Yamao Y, Nankaku M, Miyamoto S, Matsuda S, Inadomi H, Arakawa Y.
  Sci Rep, 12:216, 2022
• Cerebral tufted angioma with gradually developing peritumoral edema: A case report.
  Hasegawa T, Arakawa Y, Minamiguchi S, Mineharu Y, Nakajima S, Nakajima K, Hirose T, Haga H, Miyamoto S.
  NMC Case Rep J, 9:187-192, 2022
• The Japan Society for Neuro-Oncology guideline on the diagnosis and treatment of central nervous system germ cell tumors.
  Nakamura H, Takami H, Yanagisawa T, Kumabe T, Fujimaki T, Arakawa Y, Karasawa K, Terashima K, Yokoo H, Fukuoka K, Sonoda Y, Sakurada K, Mineharu Y, Soejima T, Fujii M, Shinojima N, Hara J, Yamasaki K, Fujimura J, Yamasaki F, Takahashi M, Suzuki T, Sato I, Nishikawa R, Sugiyama K.
  Neuro Oncol, 24:503-515, 2022

2021

• Papillary glioneuronal tumor growing slowly for 26 years: illustrative case.
  Shinno K, Arakawa Y, Minamiguchi S, Terada Y, Tanji M, Mineharu Y, Kikuchi T, Haga H, Miyamoto S.
  J Neurosurg Case Lessons, 2:CASE21266, 2021
• A randomized phase III study of short-course radiotherapy combined with Temozolomide in elderly patients with newly diagnosed glioblastoma: Japan clinical oncology group study JCOG1910 (AgedGlio-PIII).
  Arakawa Y, Sasaki K, Mineharu Y, Uto M, Mizowaki T, Mizusawa J, Sekino Y, Ono T, Aoyama H, Satomi K, Ichimura K, Kinoshita M, Ohno M, Ito Y, Nishikawa R, Fukuda H, Nishimura Y, Narita Y, Brain Tumor Study Group and Radiation Therapy Study Group of the Japan Clinical Oncology Group.
  BMC Cancer, 21:1105, 2021
• Infrequent RAS mutation is not associated with specific histological phenotype in gliomas.
  Makino Y, Arakawa Y, Yoshioka E, Shofuda T, Minamiguchi S, Kawauchi T, Tanji M, Kanematsu D, Mineharu Y, Miyamoto S, Kanemura Y.
  BMC Cancer, 21:1025, 2021
• Assessment of neurocognitive function in association with WHO grades in gliomas.
  Yamawaki R, Nankaku M, Umaba C, Ueda M, Liang N, Mineharu Y, Yamao Y, Ikeguchi R, Matsuda S, Miyamoto S, Arakawa Y.
  Clin Neurol Neurosurg, 208:106824, 2021
• Spinal cord astroblastoma with EWSR1-BEND2 fusion classified as HGNET-MN1 by methylation classification: a case report.
  Tsutsui T, Arakawa Y, Makino Y, Kataoka H, Mineharu Y, Naito K, Minamiguchi S, Hirose T, Nobusawa S, Nakano Y, Ichimura H, Haga K, Miyamoto S.
  Brain Tumor Pathol, 38:283-289, 2021
• Prognostic stratification for IDH-wild-type lower-grade astrocytoma by Sanger sequencing and copy-number alteration analysis with MLPA.
  Makino Y, Arakawa Y, Yoshioka E, Shofuda T, Kawauchi T, Terada Y, Tanji M, Kanematsu D, Mineharu Y, Miyamoto S, Kanemura Y.
  Sci Rep, 11:14408, 2021
• Preoperative obliteration of choroidal arteries in the treatment of large hypervascular tumors in the lateral ventricle.
  Yamao Y, Yoshida K, Ishii A, Tanji M, Okawa M, Mineharu Y, Kikuchi T, Arakawa Y, Kataoka H, Takagi Y, Miyamoto S.
  BMC Neurol, 21:113, 2021
• Short diameter may be a useful simple indicator of the tumor response in skull base meningiomas after conventionally fractionated stereotactic radiotherapy.
  Takehana K, Nakamura D, Abdelghaffar A, Uto M, Katagiri T, Arakawa Y, Mineharu Y, Miyamoto S, Mizowaki T.
  Eur Radiol, 31:6367-6373, 2021

2020

• Impact of intraoperative 3-Tesla MRI on endonasal endoscopic pituitary adenoma resection and a proposed new scoring system for predicting the utility of intraoperative MRI.
  Tanji M, Kataoka H, Kikuchi M, Sakamoto T, Kuwata F, Matsunaga M, Nakagawa T, Mineharu Y, Arakawa Y, Yoshida K, Miyamoto S.
  Neurol Med Chir (Tokyo), 60:553-562, 2020

2018

• CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication: a comparison with its counterparts in the kidney and soft tissue.
  Yoshida Y, Nobusawa S, Nakata S, Nakada M, Arakawa Y, Mineharu Y, Sugita Y, Yoshioka T, Araki A, Sato Y, Takeshima H, Okada M, Nishi A, Yamazaki T, Kohashi K, Oda Y, Hirato J, Yokoo H.
  Brain Pathol, 28:710-720, 2018
• Five-year outcomes following hypofractionated stereotactic radiotherapy delivered in five fractions for acoustic neuromas: the mean cochlear dose may impact hearing preservation.
  Chen Z, Takehana K, Mizowaki T, Uto M, Ogura K, Sakanaka K, Arakawa Y, Mineharu Y, Miyabe Y, Mukumoto N, Miyamoto S.
  Int J Clin Oncol, 23:608-614, 2018
• Addition of amide proton transfer imaging to FDG-PET/CT improves diagnostic accuracy in glioma grading: A preliminary study using the continuous net reclassification analysis.
  Sakata A, Okada T, Yamamoto Y, Fushimi Y, Dodo T, Arakawa Y, Mineharu Y, Schmitt B, Miyamoto S, Togashi K.
  AJNR Am J Neuroradiol, 39:265-272, 2018

2016

• Feasibility evaluation of hypofractionated radiotherapy with concurrent temozolomide in elderly patients with glioblastoma.
  Uto M, Mizowaki T, Ogura K, Arakawa Y, Mineharu Y, Miyamoto S, Hiraoka M.
  Int J Clin Oncol, 21:1023-1029, 2016
• Clinicopathological, radiological, and genetic analyses of cerebellar gangliogliomas with long-term survival.
  Liu B, Arakawa Y, Murata D, Mineharu Y, Yokogawa R, Tanji M, Fujimoto KI, Fukui N, Terada Y, Miyamoto S.
  World Neurosurg, 94:521-528, 2016

2015

• Familial schwannomatosis with a germline mutation of SMARCB1 in Japan.
  Asai K, Tani S, Mineharu Y.
  Brain Tumor Pathol, 32:216-220, 2015

2014

• Intracranial germinomas in a father and his son.
  Shimizu K, Mineharu Y, Imamura H, Asai K, Imai Y, Ichimura K, Sakai N.
  Childs Nerv Syst, 30:2143-2146, 2014

2012

• Gene therapy for brain tumors: basic developments and clinical implementation.
  Assi H, Candolfi M, Baker G, Mineharu Y, Lowenstein PR, Castro MG.
  Neurosci Lett, 527:71-77, 2012

2009

• Effect of early optic canal unroofing on the outcome of visual functions in surgery for meningiomas of the tuberculum sellae and planum sphenoidale.
  Nozaki K, Kikuta KI, Takagi Y, Mineharu Y, Takahashi JA, Hashimoto N.
  Neurosurgery, 62:839-844, 2009

Others

2025

• Clinical Features in Patients with Delayed Exposure of Titanium Plates and Meshes after Cranioplasty.
  Sano N, Yamamoto Hattori E, Ikeda H, Takada S, Tanji M, Mineharu Y, Arakawa Y.
  Neurol Med Chir (Tokyo), 65:632-637, 2025
• Single pulse electrical stimulation of the medial thalamic surface induces narrower high gamma band activities in the sensorimotor cortex.
  Nakamura Y, Usami K, Yamanaka H, Yamada D, Mineharu Y, Kikuchi T, Matsuhashi M, Arakawa Y, Kunieda T.
  Sci Rep, 15:22335, 2025

2024

• Cerebral cavernous malformation with prolonged postoperative paralysis due to perilesional inflammation: illustrative case.
  Inai S, Sano N, Takeuchi Y, Makino Y, Yamamoto Hattori E, Takada S, Tanji M, Mineharu Y, Arakawa Y.
  J Neurosurg Case Lessons, 8:CASE24570, 2024

2021

• Factors associated with somnolence during brain function mapping in awake craniotomy.
  Mizota T, Hamada M, Shiraki A, Kikuchi T, Mineharu Y, Yamao Y, Hattori EY, Yonezawa A, Furukawa K, Arakawa Y.
  J Clin Neurosci, 89:349-353, 2021

2020

• Effects of low-dose remifentanil infusion on analgesic or antiemetic requirement during brain function mapping: A retrospective cohort study.
  Shiraki A, Goto W, Fukagawa H, Arakawa Y, Kikuchi T, Mineharu Y, Yamao Y, Yasuda T, Hattori E, Fukui A, Matsui Y, Yonezawa A, Furukawa K, Mizota T.
  Acta Anaesthesiol Scand, 64:735-741, 2020

2019

• Successful reperfusion with endovascular therapy has beneficial effects on long-term outcome beyond 90 days.
  Todo K, Sakai N, Imamura H, Yamagami H, Adachi H, Kono T, Kobayashi J, Yamamoto S, Morimoto T, Tani S, Kawamoto M, Sakaguchi M, Ueno Y, Kunieda T, Narumi O, Sakai C, Ishii A, Hoshi T, Koyanagi M, Mineharu Y, Ishikawa T, Kuramoto Y, Sato S, Ohara N, Arimura K, Nakamura H, Nishida T, Gon Y, Fujinaka T, Yoshiya K, Kishima H, Mochizuki H, Kohara N, KCGH-CSC Registry Investigators.
  Cerebrovasc Dis, 47:127-134, 2019

2018

• Postoperative in-stent protrusion is an important predictor of perioperative ischemic complications after carotid artery stenting.
  Beppu M#, Mineharu Y#, (# equal contribution) Imamura H, Adachi H, Sakai C, Tani S, Arimura K, Tokunaga S, Sakai N.
  J Neuroradiol, 45:357-361, 2018

2017

• Onyx extravasation during embolization of a brain arteriovenous malformation.
  Ikeda H, Imamura H, Agawa Y, Imai Y, Tani S, Adachi H, Ishikawa T, Mineharu Y, Sakai N.
  Interv Neuroradiol, 23:200-205, 2017
• Cerebral amyloid angiopathy in a young man with a history of traumatic brain injury: a case report and review of the literature.
  Nakayama Y, Mineharu Y, Arakawa Y, Nishida S, Tsuji H, Miyake H, Yamaguchi M, Minamiguchi S, Takagi Y, Miyamoto S.
  Acta Neurochir, 159:15-18, 2017

2016

• Effectiveness of neuroendoscopic ventricular irrigation for ventriculitis.
  Terada Y, Mineharu Y, Arakawa Y, Funaki T, Tanji M, Miyamoto S.
  Clin Neurol Neurosurg, 146:147-151, 2016
• Effect of coil packing proximal to the dilated segment on postoperative medullary infarction and prognosis following internal trapping for ruptured vertebral artery dissection.
  Ikeda H, Imamura H, Mineharu Y, Tani S, Adachi H, Sakai C, Ishikawa T, Asai K, Sakai N.
  Interv Neuroradiol, 22:67-75, 2016
• Histopathological features of brain arteriovenous malformations in Japanese patients.
  Hermanto Y, Takagi Y, Yoshida K, Ishii A, Kikuchi T, Funaki T, Mineharu Y, Miyamoto S.
  Neurol Med Chir (Tokyo), 56:340-344, 2016
• Bilateral chronic subdural hematoma is associated with rapid progression and poor clinical outcome.
  Agawa Y, Mineharu Y, Tani S, Adachi H, Imamura H.
  Neurol Med Chir (Tokyo), 56:198-203, 2016

2015

• Immunohistochemical analysis Sox17 associated pathway in brain arteriovenous malformations.
  Hermanto Y, Takagi Y, Ishii A, Yoshida K, Kikuchi T, Funaki T, Mineharu Y, Miyamoto S.
  World Neurosurg, 87:573-583, 2015
• Carotid artery dissection caused by an elongated styloid process: Three case reports and review of the literature.
  Ogura T, Mineharu Y, Todo K, Kohara N, Sakai N.
  NMC Case Rep J, 1:21-25, 2015
• Traumatic arteriovenous fistula of the superficial temporal artery.
  Asai K, Tani S, Imai Y, Mineharu Y, Sakai N.
  J Surg Case Rep, 2015:rjv156, 2015
• Stenting for acute cerebral venous sinus thrombosis in the superior sagittal sinus.
  Adachi H, Mineharu Y, Ishikawa T, Imamura H, Yamamoto S, Todo K, Yamagami H, Sakai N.
  Interv Neuroradiol, 21:719-723, 2015
• X-ray angiography perfusion analysis for the balloon occlusion test of the internal carotid artery.
  Asai K, Imamura H, Mineharu Y, Tani S, Adachi H, Narumi O, Todo K, Hoshi T, Sato S, Sakai N.
  J Stroke Cerebrovasc Dis, 24:1506-1512, 2015

2014

• Triple balloon protection technique using the MoMa Ultra with the carotid GuardWire for carotid stenting: Technical note.
  Asai K, Imamura H, Mineharu Y, Tani S, Adachi H, Narumi O, Todo K, Hoshi T, Sato S, Kono T et al.
  J Stroke Cerebrovasc Dis, 23:1871-1876, 2014

2013

• Coexistence of multiple cavernous angiomas in the spinal cord and skin: a unique case of Cobb syndrome.
  Matsui Y, Mineharu Y, Satow T, Takebe N, Takeuchi E, Saiki M.
  J Neurosurg Spine, 20:142-147, 2013

2007

• Combination of linkage and association studies for brain arteriovenous malformation.
  Inoue S, Liu W, Inoue K, Mineharu Y, Takenaka K, Yamakawa H, Abe M, Jafar JJ, Herzig R, Koizumi A.
  Stroke, 38:1368-1370, 2007

2004

• Linear deposition of immunoglobulins and complement components on the dura in normal pressure hydrocephalus complicating systemic lupus erythematosus.
  Honda K, Matsumoto M, Kaneko T, Kamei I, Tatsumi H, Murai N, Mineharu Y, Oita J.
  J Clin Neurosci, 11:561-563, 2004